Introduction: Probiotics are living microorganisms whose administration in sufficient quantities improves the health of their host. Probiotics are naturally found in fermented or supplemental foods. Prebiotics are non-digestible foods that play an important role in the growth and proliferation of bacteria in the gut.Methods: This is a review study using multiple sources on the application and role of probiotics and prebiotics in human health through library and internet search and using probiotic, prebiotic keywords and their role in human health. , Bacteriobactylobacter and bifidobacter have been carried out in Persian and English on pubmed, sid, science direct, medline, scopous and iranmedex sites. Results: Epidemiological studies have shown that the use of probiotic and prebiotic by preserving normal intestinal microflora and controlling pathogenic microorganisms reduce the risk of cancer, improve heart health and lower blood pressure and lower cholesterol, improve liver disease. Strengthening the immune system, reducing menopausal symptoms, improving digestive and urinary health, anti-inflammatory, antimicrobial and antiviral effects, lowering blood pressure, reducing the risk of osteoporosis and preventing weight gain and obesity. Probiotic dairy products around the world, especially Iran, comprise a large portion of the probiotic industry, which has been highly welcomed by the general public. Conclusion: Nowadays probiotic and prebiotic products have a special place in the world because of their therapeutic properties and beneficial effects on health and their production is highly appreciated in the world. They generally prevent many diseases and prolong human life.
