Student life, while offering new opportunities for the individual, also has its own challenges and tensions. The purpose of this study was to determine the effectiveness of theater therapy on the quality of life of students.Method: This research is a pretest-posttest design with experimental and control groups.The statistical population included all students of Mashhad University of Medical Sciences during the second semester of academic year 2016-2015who were selected through simple random sampling among 30 applicants. They were randomly divided into two experimental and control groups.In this research, the quality of life of the students was used from the short form of health surveillance SF6 three times before the beginning of the treatment after the end of the sessions and follow up one month after the completion of the treatment, which was completed by the two groups.For the experimental group, 8 sessions of theater therapy were performed and the control group did not receive any therapeutic intervention.Results: The findings of multivariate covariance analysis showed that the theater therapy is a suitable method for improving the quality of life of students.(p<0.05)Conclusion: The therapeutic effect on the quality of life of students includes general health physical activity limitation for physical reasons physical pain limitation for the emotional causes of social action have affected fatigue and vitality and emotional problems.