Todays, more attention is paid to the psychological care of the elderly since they are exposed to potential threats related to increased age, loneliness, social isolation, and physical and mental disabilities. Therefore, this study aimed to investigate the mediating role of death anxiety in the relationship between social support and psychological well-being in the elderly. One hundred and ninety-three aged people with an average age of 65 years were selected from Shiraz city by available sampling. The participants filled in the social support scale, the scale of death anxiety, and the psychological well-being scale. Were obtained from structural equation modeling using AMOS 23 software. The result of this study indicated the direct effect of social support on well-being but did not confirm the mediating role of death anxiety. Another finding was the direct and significant effect of death anxiety on well-being. Social iteraction leads to increased psychological well-being in the elderly, meanwhile death anxiety endangers their psychological well-being.