Formation of coordination bonds between metal ions and organic ligands has led to the development of a new class of material named metal-organic frameworks (MOFs). The highly porous structure with adjustable size, shape, composition and capability of surface modification has made them an interesting object for drug delivery applications. The present paper tried to review the recent advances in the synthesis of nano MOFs as drug carriers, drug loading methods and also described the interactions of MOFs with the biological medium. Finally, perspectives, challenges and future outlooks in the development of MOFs for drug delivery applications have been discussed.
